How monocytes guard the glomerulus

Patrolling monocytes promote intravascular neutrophil activation and glomerular injury in the acutely inflamed glomerulus.

Nonclassical monocytes undergo intravascular patrolling in blood vessels, positioning them ideally to coordinate responses to inflammatory stimuli. Under some circumstances, the actions of monocytes have been shown to involve promotion of neutrophil recruitment. However, the mechanisms whereby patrolling monocytes control the actions of neutrophils in the circulation are unclear. Here, we exami...

How to guard a graph against tree movements

This paper shows that the optimization problem arising from the guarding game played between the cop and robber players on an undirected graph can be approximated within a factor of Θ(logn) when the robber region is a tree.

Building the glomerulus: a matricentric view.

T he structural integrity of the glomerular capillaries stems from the stereotyped arrangement of the three constituent cell types: Podocytes (also called visceral epithelial cells), endothelial cells, and mesangial cells. The arrangement of these cells depends in part on their interactions with extracellular matrix, most notably the glomerular basement membrane (GBM). In this essay, I discuss ...

An energy budget for the olfactory glomerulus.

Energy demands are becoming recognized as an important constraint on neural signaling. The olfactory glomerulus provides a well defined system for analyzing this question. Odor stimulation elicits high-energy demands in olfactory glomeruli where olfactory axons converge onto dendrites of olfactory bulb neurons. We performed a quantitative analysis of the energy demands of each type of neuronal ...

Dissecting the Role of Vegf-a in the Glomerulus – Insights into the Adult Glomerulus and Renal Disease